cssDNA as the Next Frontier in Genetic Medicine

Circular single-stranded DNA (cssDNA) is emerging as a powerful new modality in genetic medicine. Once limited by manufacturing challenges, advances in enzymatic production have unlocked its potential as a stable, programmable, and potentially less immunogenic platform for gene replacement and cell engineering. From precise CRISPR donor templates to in vivo immune programming, cssDNA may help complete the genetic medicine toolkit — shifting the field from simply editing genes to installing new biological instructions with intention.